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Ambra1 antibody
Activating molecule in BECN1-regulated autophagy protein 1
autophagy/beclin 1 regulator 1
Gene name: Ambra1, Kiaa1736
autophagy/beclin 1 regulator 1
Gene name: Ambra1, Kiaa1736
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00013214
Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation
| ID Covalab | pab0224 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein. |
| Activity cross reaction | Reacts with mouse 120 kDa Ambra1 protein. Cross reacts with human and rat protein. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) |
| Uniprot ID | Q9C0C7 |
| Gene ID | 55626 |
| Applications | ELISA, EM, IF, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. |
| Publication | * Manganelli V et al. The Role of Cardiolipin as a Scaffold Mitochondrial Phospholipid in Autophagosome Formation: In Vitro Evidence, Biomolecules, Feb 2021 * Manganelli V et al. Raft-like lipid microdomains drive autophagy initiation via AMBRA1-ERLIN1 molecular association within MAMs. Autophagy. 2020 Oct 9. * AS Puebla, Lysosome-dependent cell death: molecular players and implications for disease, PhD thesis in biology, director P Boya, University Complutense of Madrid, 2019 (IF, Ms) * Rodríguez-Muela N et al. Cell Death Differ. 2015 Mar,22(3):476-87.(IHC-F, Ms) * Pagliarini V et al. Cell Death Differ. 2012 Sep,19(9):1495-504. (WB, Hu) * Paronetto M.P et al. Peptidic and peptidomimetic compound for regulating autophagy. US Patent Application. 2011 Nov : 20110281804. * Armstrong J.L. et al. Clin Cancer Res. 2011 Apr 15,17(8):2216-26.(WB, Hu) * Di Bartolomeo S.et al. J Cell Biol. 2010 Oct 4,191(1):155-68.(IF, EM, Hu) * Fimia G.M. et al. Nature. 2007 Jun 28,447(7148):1121-5. |
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