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Alpha-actinin-4 (ACTN4) antibody
F-actin cross-linking protein
Non-muscle alpha-actinin 4
Gene name: ACTN4
Non-muscle alpha-actinin 4
Gene name: ACTN4
As low as
€278.30
In stock
Ref
00013219
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions.
| ID Covalab | pab0221 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from N- term domain of the human ACTN4 protein. |
| Activity cross reaction | Reacts with human 110 kDa of ACTN4 protein. Cross reacts with rat and mouse protein due to sequence homology. |
| Species | Hu |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Alpha-actinin-4 (ACTN4) |
| Uniprot ID | O43707 |
| Gene ID | 81 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - IHC : 1/100 to 1/500 - WB : 1/500 to 1/2 000 |
| Publication | - Celli L. et al. Evidence of a Functional Role for Interaction between ICAM-1 and Nonmuscle -Actinins in Leukocyte Diapedesis. The Journal of Immunology; 2006, 177: 4113-4121. |
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