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CRMP-4 antibody
Dihydropyrimidinase-related protein 3 (DRP-3)
Unc-33-like phosphoprotein 1 (ULIP-1)
Gene name: DPYSL3, CRMP4, DRP3, ULIP, ULIP1
Unc-33-like phosphoprotein 1 (ULIP-1)
Gene name: DPYSL3, CRMP4, DRP3, ULIP, ULIP1
As low as
€294.00
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00013391
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration
| ID Covalab | pab0117-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator |
| Activity cross reaction | Reacts with 65 kDa CRMP-4 from human rat and mouse. Do not react with CRMP-1, CRMP-2, CRMP-3 or CRMP-5. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Collapsin response mediator protein 4 (CRMP-4) |
| Uniprot ID | Q14195 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : -IHC : 1/500 - WB :1/2 000 |
| Publication | - Blasco H et al. A rare Motor Neuron Deleterious Missense Mutation in the DPYSL3 (CRMP4) Gene is Associated with ALS. Hum Mutat. 2013 Apr 8. - Duplan L. et al. Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death. J Neurosci. 2010 Jan 13;30(2):785-96. - Veyrac A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci. 2005;21:2635-48. - Bertin S. et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17. - Quach T. et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol Cell Neurosci. 2004;25:433-43. - Charrier E. et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol Neurobiol. 2003;28:51-64. - Ricard D et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001 ; 21:7203-14. - Honnorat J. et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32. - Balin BJ, et al. Analysis of transglutaminase-catalyzed isopeptide bonds in paired helical filaments and neurofibrillary tangles from Alzheimer's disease.Methods Enzymol. 1999;309:172-86. |
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