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Phospholipase C-zeta-1 (PLC-zeta-1) antibody
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1, PLCζ
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1, PLC-zeta-1
Testis-development protein NYD-SP27
Gene name: PLCZ1
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1, PLC-zeta-1
Testis-development protein NYD-SP27
Gene name: PLCZ1
As low as
€294.00
In stock
Ref
00014409
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.
| ID Covalab | pab0367-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from internal part of PLC-zeta-1 |
| Activity cross reaction | Reacts with human PLC zeta protein. No cross reaction |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Phospholipase C-zeta-1 |
| Uniprot ID | Q86YW0 |
| Applications | ELISA, ICC, IF, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IHC (10 µg/ml) WB (10 µg/ml) |
| Publication | * Hua R. et al. Hum Reprod. 2023 Mar. (IF, WB) * Dai J. et al. Mol Hum Reprod. 2022 Jul 21:gaac028 * M Lv et al. Reprod Biol Endocrinol. 2022 Jan 3:20(1):5 (IF, Hu) * Xin A et al. Science Advances. 2020 Sep 01 (WB, IF, Hu) * Rahimizadeh P et al. Mol Reprod Dev. 2019 Nov 17 * Torra-Massana M et al. Hum Reprod. 2019 Jul 26. (WB, Hu) * Khakpour S et al. Andrologia. 2019 March 15 (Hu) * Tavalaee M et al. Reproductive BioMedicine Online. 2017 Dec * Kamali-Dolat Abadi M et al. Cell J. 2016 Fall;18(3):438-45. (WB, Hu) * Ferrer-Vaquer A et al. J Assist Reprod Genet. 2016 Jun,33(6):747-56. (WB) * Aarabi M et al. Fertil Steril. 2014 Aug,102(2):440-7. * Kashir J et al. Fertil Steril. 2013 Jan,99(1):107-17. (ICC, Hu) * Aarabi M et al. PLoS One. 2012,7(3):e33496. (IHC, ICC / Ms, Hu) * Kashir J et al. Reprod Biomed Online. 2011 Aug,23(2):263-7. (ICC, Hu) * Young C et al. Fertil Steril. 2009 May,91(5 Suppl):2230-42. * Grasa P et al. Hum Reprod. 2008 Nov,23(11):2513-22. (WB) |
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