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Phospholipase C-zeta-1 (PLC-zeta-1) antibody
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1 (PLC-zeta-1)
Testis-development protein NYD-SP27
Gene name: PLCZ1
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1 (PLC-zeta-1)
Testis-development protein NYD-SP27
Gene name: PLCZ1
As low as
€278.30
In stock
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00014412
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion.
| ID Covalab | pab0367 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from internal part of PLC-zeta-1 |
| Activity cross reaction | Reacts with human PLC zeta protein. No cross reaction |
| Species | Hu |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Phospholipase C zeta isoform (PLC-zeta-1) |
| Uniprot ID | Q86YW0 |
| Gene ID | 89869 |
| Applications | ELISA, ICC, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB (1:100 - 1:1000) ICC (1:50 - 1:1000) |
| Publication | * Rahimizadeh P et al. Mol Reprod Dev. 2019 Nov 17 * Kamali-Dolat Abadi M et al. Cell J. 2016 Fall;18(3):438-45. (WB, Hu) * Ferrer-Vaquer A et al. J Assist Reprod Genet. 2016 Jun,33(6):747-56. (WB) * Aarabi M et al. Fertil Steril. 2014 Aug;102(2):440-7. * Kashir J et al. Fertil Steril. 2013 Jan,99(1):107-17. (ICC, Hu) * Aarabi M et al. PLoS One. 2012,7(3):e33496. (IHC, ICC / Ms, Hu) * Kashir J et al. Reprod Biomed Online. 2011 Aug,23(2):263-7. (ICC, Hu) * Young C et al. Fertil Steril. 2009 May,91(5 Suppl):2230-42. * Grasa P et al. Hum Reprod. 2008 Nov,23(11):2513-22. (WB) |
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