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Saposin-B / Proactivator polypeptide (PSAP) antibody
Saposin-B-Val
Cerebroside sulfate activator (CSAct)
Dispersin
Sphingolipid activator protein 1 (SAP-1)
Sulfatide/GM1 activator
Gene name: PSAP, GLBA, SAP1
Cerebroside sulfate activator (CSAct)
Dispersin
Sphingolipid activator protein 1 (SAP-1)
Sulfatide/GM1 activator
Gene name: PSAP, GLBA, SAP1
As low as
€278.30
In stock
Ref
00014688
The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins).
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.
Saposin-D is a specific sphingomyelin phosphodiesterase activator.
Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases.
Saposin-D is a specific sphingomyelin phosphodiesterase activator.
| ID Covalab | pab0553 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from an internal domain of human PSAP |
| Activity cross reaction | Reacts with human Saposin-B. May cross react with proteins from other species due to sequence homology |
| Species | Hu |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Proactivator polypeptide domain Saposin-B (PSAP) |
| Uniprot ID | P07602 |
| Gene ID | 5660 |
| Applications | ELISA, ICC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ICC 1:200 - 1:1 000 WB 1:500 - 1:5 000 |
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