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ADAMTS4 (Internal) antibody
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4)
ADMP-1
Aggrecanase-1
Gene name : ADAMTS4, KIAA0688
ADAMTS-2
ADMP-1
Aggrecanase-1
Gene name : ADAMTS4, KIAA0688
ADAMTS-2
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00015648
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
| ID Covalab | pab70255 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic 19 amino acid peptide from internal region of human ADAMTS4. Percent identity with other species by BLAST analysis: Human (100%), Orangutan (100%), Gibbon (95%), Marmoset (95%), Monkey (89%), Elephant (89%), Horse (89%), Bovine (84%) |
| Activity cross reaction | Reacts with human ADAMTS4. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Species | Hu |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.1% |
| Storage instructions | Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C. |
| Target | ADAMTS4 |
| Accession Number | O75173 |
| Applications | IHC - P |
| Working dilutions | IHC - P (8 µg/ml) |
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