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APH1A (N-Terminus) antibody
Gamma-secretase subunit APH-1A (APH-1a)
Aph-1alpha
Presenilin-stabilization factor
APH1A, 6530402N02Rik, APH-1, APH-1A, CGI-78
Aph-1alpha
Presenilin-stabilization factor
APH1A, 6530402N02Rik, APH-1, APH-1A, CGI-78
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00015804
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Belongs to the APH-1 family. Implicated in Notch signaling pathway.
Belongs to the APH-1 family. Implicated in Notch signaling pathway.
| ID Covalab | pab70333 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from human APH1A. |
| Activity cross reaction | Reacts with 13 amino acid peptide from near the amino terminus of human APH1a. |
| Species | Hu, Ms |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted. |
| Target | APH1A |
| Accession Number | Q96BI3 |
| Applications | IHC - P, WB |
| Working dilutions | IHC - P (3, 2.5 µg/ml), WB |
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