mTOR (N-Terminus) antibody

Serine/threonine-protein kinase mTOR
FK506-binding protein 12-rapamycin complex-associated protein 1
FKBP12-rapamycin complex-associated protein
Mammalian target of rapamycin, mTOR
Mechanistic target of rapamycin
Rapamycin and FKBP12 target 1
Rapamycin target protein 1
Gene name: MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1
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00018680
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E).
More Information
ID Covalab pab71788
Product type Primary antibodies
Clonality Polyclonal antibody
Raised in Rabbit
Immunogen Synthetic peptide near the amino terminus of human mTOR.
Activity cross reaction Reacts with the N-terminus part of human TOR. Cross reacts with mouse protein.
Species Hu, Ms
Labelling None
Form Antigen affinity purified
Preservative NaN3 0.02%
Storage instructions Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
Target mTOR
Uniprot ID P42345
Gene ID 2475
Applications ICC, IHC - P, WB
Working dilutions Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC-P (5 µg/ml),
WB (1 µg/ml)
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