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DDIT3 / GADD153 antibody
DNA damage-inducible transcript 3 protein, DDIT-3
C/EBP zeta
C/EBP-homologous protein, CHOP
C/EBP-homologous protein 10, CHOP-10
CCAAT/enhancer-binding protein homologous protein
Growth arrest and DNA damage-inducible protein GADD153
Gene name: DDIT3, CHOP, CHOP10, GADD153
C/EBP zeta
C/EBP-homologous protein, CHOP
C/EBP-homologous protein 10, CHOP-10
CCAAT/enhancer-binding protein homologous protein
Growth arrest and DNA damage-inducible protein GADD153
Gene name: DDIT3, CHOP, CHOP10, GADD153
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00026403
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.
| ID Covalab | pab75228 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Recombinant human GADD153. |
| Activity cross reaction | Reacts with human, mouse and rat DDIT3 / GADD153. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | 0.02% Thimerosal |
| Storage instructions | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Target | DDIT3 / GADD153 |
| Uniprot ID | P35638 |
| Gene ID | 1649 |
| Applications | IHC - P, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IHC - P (5 µg/ml) |
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