We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
GSK3B / GSK3 Beta antibody
Glycogen synthase kinase-3 beta
Serine/threonine-protein kinase GSK3B, Gsk 3beta, GSK-3 beta, GSK3 beta, GSK3beta
Gene name: GSK3B
Serine/threonine-protein kinase GSK3B, Gsk 3beta, GSK-3 beta, GSK3 beta, GSK3beta
Gene name: GSK3B
Out of stock
Ref
00026409
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC, AXIN1, DPYSL2/CRMP2, JUN, NFATC1/NFATC, MAPT/TAU and MACF1. Requires primed phosphorylation of the majority of its substrates. In skeletal muscle, contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis.
| ID Covalab | pab75234 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from the sequence of rat GSK3 beta, conjugated to KLH. Sequence identical to human. |
| Activity cross reaction | Reacts with rat GSK3B / GSK3 Beta. Cross reacts with bovine, human and mouse protein. |
| Species | Bov, Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | 0.09% NaN3 |
| Storage instructions | Store at -20°C. |
| Target | GSK3B / GSK3 Beta |
| Uniprot ID | P49841 |
| Gene ID | 2932 |
| Applications | IF, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC - P (10 µg/ml), WB (1:1000) |
Write Your Own Review