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BCL2 / Bcl-2 antibody
B-cell CLL/lymphoma 2, B-cell lymphoma protein 2, Bcl-2
Gene name: BCL2, PPP1R50
Gene name: BCL2, PPP1R50
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00026450
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
| ID Covalab | pab75275 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Isotype | IgG |
| Raised in | Rabbit |
| Immunogen | Recombinant human protein purified from E. coli (His-Bcl-2 1-211 a.a.). |
| Activity cross reaction | Reacts with human BCL2 / Bcl-2. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | 0.03% NaN3 |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | Apoptosis regulator Bcl-2 |
| Uniprot ID | P10415 |
| Gene ID | 596 |
| Applications | IHC - P, WB |
| Working dilutions | IHC - P (1:100), WB (1:2000) |
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