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MAPK1 / ERK antibody
Mitogen-activated protein kinase 1, MAP kinase 1, MAPK 1
ERT1
Extracellular signal-regulated kinase 2, ERK-2
MAP kinase isoform p42, p42-MAPK
Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
Gene name: MAPK1, ERK2, PRKM1, PRKM2
ERT1
Extracellular signal-regulated kinase 2, ERK-2
MAP kinase isoform p42, p42-MAPK
Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
Gene name: MAPK1, ERK2, PRKM1, PRKM2
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00028408
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
| ID Covalab | mab71410 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Isotype | IgG1 / Kappa |
| Raised in | Mouse |
| Immunogen | His-tagged recombinant human Erk2 protein purified from E. coli. |
| Activity cross reaction | Reacts with human MAPK1 / ERK. Cross reacts with mouse and rat protein. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified |
| Preservative | 0.03% NaN3 |
| Storage instructions | Long term: -20°C; Short term: -20°C |
| Target | MAPK1 / ERK |
| Uniprot ID | P28482 |
| Gene ID | 5594 |
| Applications | ELISA, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC-P (1:50), WB (1:1000) |
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