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LC3A antibody
Microtubule-associated proteins 1A/1B light chain 3B
Autophagy-related protein LC3 B
Autophagy-related ubiquitin-like modifier LC3 B
MAP1 light chain 3-like protein 2
MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B
Microtubule-associated protein 1 light chain 3 beta
Gene name: MAP1LC3B, MAP1ALC3
Autophagy-related protein LC3 B
Autophagy-related ubiquitin-like modifier LC3 B
MAP1 light chain 3-like protein 2
MAP1A/MAP1B light chain 3 B, MAP1A/MAP1B LC3 B
Microtubule-associated protein 1 light chain 3 beta
Gene name: MAP1LC3B, MAP1ALC3
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00030672
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
| ID Covalab | pab50207 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide made to an internal portion of the human LC3A protein sequence (between residues 50-150) |
| Activity cross reaction | Reacts with LC3A from human, mouse, rat, Zebrafish and plants. Predicted to react with Xenopus and bovine based on 100% sequence homology. |
| Species | Hu, Ms, Pl, Rat, Zfi |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.05% |
| Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Target | Light Chain 3A, LC3A |
| Uniprot ID | Q9GZQ8 |
| Gene ID | 84557 |
| Applications | ICC, IF, IHC - P, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: ICC/IF (1:100-1:300) IHC (1:200 - 1:400) IHC-P (1:200 - 1:400) IP (20 µl / 500 µg of lysate) WB (2 ug/ml) |
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