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ATG16L1 / ATG16L (C-Terminus) antibody
Autophagy-related protein 16-1, APG16-like 1, WD repeat domain 30
Gene name: ATG16L1, APG16L, APG16L beta, ATG16L, IBD10, ATG16A, WDR30
Gene name: ATG16L1, APG16L, APG16L beta, ATG16L, IBD10, ATG16A, WDR30
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00038292
Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
| ID Covalab | pab75590 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Goat |
| Immunogen | Synthetic peptide C-KVEKVLSKQHSSSIN from an internal region (near the C-terminus) of human ATG16L1 (NP_110430.5; NP_060444.3). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Opossum (100%). |
| Activity cross reaction | Reacts with the C-terminus part of human ATG16L1 / ATG16L. Cross reacts with mouse, monkey, rat ans hamster protein. This antibody is expected to recognize both reported isoforms (NP_110430.5 and NP_060444.3). |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | 0.02% NaN3 |
| Storage instructions | Store at -20°C. Minimize freezing and thawing. |
| Target | ATG16L1 / ATG16L |
| Uniprot ID | Q676U5 |
| Gene ID | 55054 |
| Applications | ELISA, IHC - P |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: ELISA 1:32000, IHC-P 3.75 µg/ml |
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