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Chromo domain-containing protein LHP1 antibody
Protein LIKE HETEROCHROMATIN PROTEIN 1
Protein TERMINAL FLOWER 2
Gene name: LHP1, TFL2, TU8, At5g17690, MVA3.4
Protein TERMINAL FLOWER 2
Gene name: LHP1, TFL2, TU8, At5g17690, MVA3.4
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00038956
Structural component of heterochromatin involved in gene repression, including several floral homeotic genes and FLT that regulates flowering time. Required for maintenance of vernalization-induced repression of FLC. As part of the PRC1-like complex, recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me), leading to epigenetic repression. PcG PRC1 complex maintains the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility
| ID Covalab | pab0923-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from a C terminal domain of Chromo domain-containing protein LHP1 from Arabidopsis thaliana. |
| Activity cross reaction | Reacts with Chromo domain-containing protein LHP1 Arabidopsis thaliana (Mouse-ear cress). |
| Species | A. thal. |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Chromo domain-containing protein LHP1 |
| Uniprot ID | Q946J8 |
| Applications | ELISA, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: - WB : 1/500 to 1/5 000 |
| Publication | * C Fonouni-Farde et al. The Arabidopsis APOLO and human UPAT sequence-unrelated long noncoding RNAs can modulate DNA and histone methylation machineries in plants, Genome biology, 2022 Aug 29;23(1):181 * C Fonouni-Farde et al. Sequence-unrelated long noncoding RNAs converged to modulate the activity of conserved epigenetic machineries across kingdoms, bioRxiv, 2021 Feb 27 * Ariel F et al. Mol Cell. 2020 Jan 6. pii: S1097-2765(19)30928-1 |
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