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Nucleophosmin (mutant) antibody
Nucleophosmin, NPM
Nucleolar phosphoprotein B23
Nucleolar protein NO38
Numatrin
Gene name: NPM1, NPM
Nucleolar phosphoprotein B23
Nucleolar protein NO38
Numatrin
Gene name: NPM1, NPM
As low as
€480.40
In stock
Ref
00096131
Nucleophosmin (NPM) is a multi-functional protein that is involved in many cellular activities including cell growth, proliferation and transformation. It is frequently overexpressed in solid tumors, and has recently been found to be mutated and aberrantly localized in the cytoplasm of leukaemic blasts in patients with acute myeloid leukemia (AML).
| ID Covalab | pab50321 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide made to a C-terminal region of human mutant nucleophosmin (within residues 250-294) [AAW67752] |
| Activity cross reaction | Reacts with the mutant form of Nucleophosmin. |
| Species | Hu |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Nucleophosmin, mutant |
| Uniprot ID | P06748 |
| Gene ID | 4869 |
| Applications | FC, IF, IHC - P, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : FC (1:100) ICC/IF (1:50 - 1:100) IHC - P (1:50 - 1:100) IP (1:50) WB (1:1000) |
| Publication | * Holoubek A. et al. AML-related NPM mutations drive p53 delocalization into the cytoplasm with possible impact on p53-dependent stress response (WB) * Šašinková M. et al. Sci Rep. 2021 Jan 13:11(1):1084 (WB) * Šašinková M. Int J Biochem Cell Biol. 2018 Aug 18. pii: S1357-2725(18)30179-1 |
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