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Lipase A antibody
Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL)
Cholesteryl esterase
Lipase A
Sterol esterase
Gene name: LIPA
Cholesteryl esterase
Lipase A
Sterol esterase
Gene name: LIPA
As low as
€480.40
In stock
Ref
00096264
Lipase A is a critical enzyme for metabolism, sequestration and degradation of cholesterol. When LIPA is not effective in liver and kidney cells, lipoprotein cholesterol accumulates and leads to atherosclerosis, inflammation, Type 2 diabetes, and chronic kidney disease. In Wolman disease, deficiency of LIPA causes buildup of cholesterol in spleen, liver, bone marrow, intestine, adrenal glands and lymph nodes, which eventually causes such toxicity in children affected that they rarely live past 1 year of age. Intracellularly, LIPA mediates the uptake of cholesterol by the endosomal/lysosomal compartment, and hydrolyzes cholesterol esterases.
| ID Covalab | pab52806 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | A genomic peptide made to an internal region of the human Lysosomal acid lipase protein (within residues 150-300). [Swiss-Prot P38571] |
| Activity cross reaction | Reacts with LIPA protein human and mouse. May cross reacts with pig (82% sequence homology), rat and cow (73%). |
| Species | Hu, Ms |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Lipase A |
| Uniprot ID | P38571 |
| Applications | ICC, IF, IHC - P, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : - ICC : 1/50 to 1/100 - IF : 1/50 to 1/100 - IHC - P : 1/100 - WB : 1/10000 |
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