We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Amyloid Beta 1-16 (Ab3) antibody
Amyloid beta A4 protein
ABPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Gene name: APP, A4, AD1
ABPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Gene name: APP, A4, AD1
As low as
€600.00
In stock
Ref
00096540
Accumulation and aggregation of amyloid β (Aβ) in the brain is indicated as the trigger of a pathological cascade that causes Alzheimer disease (AD). There is now compelling evidence that metal binding to Aβ is involved in AD pathogenesis. The amino acid region 1-16 is widely considered as the metal binding domain of Aβ. Unlike copper(II) that prefers the N-terminal amino group as the main binding site, zinc(II) is preferentially placed in the 8-16 amino acidic region of Aβ (1-16).
| ID Covalab | mab60027 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | Ab3 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Synthetic peptide corresponding to Aβ1-16. |
| Activity cross reaction | Reacts with human and mouse Aβ1-16 as well as other Aβ peptides: Aβ37, Aβ38, Aβ39, Aβ40 and Aβ42 |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified |
| Preservative | None |
| Storage instructions | Stable for at least one year at -20°C |
| Target | Amyloid Beta 1-16 |
| Uniprot ID | P05067 |
| Gene ID | 351 |
| Applications | ELISA, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: 1 - 10 µg/ml for any applications |
| Publication | Levites Y et al. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. FASEB J. 2006 Dec:20(14):2576-8. Levites Y et al. Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. J Neurosci. 2006 Nov15:26(46):11923-8. Levites Y et al. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest. 2006 Jan:116(1):193-201. |
Write Your Own Review