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Chapsyn-110 (S18-30) antibody
Disks large homolog 2
Channel-associated protein of synapse-110, Chapsyn-110
Postsynaptic density protein PSD-93
Gene name: Dlg2, Dlgh2
Channel-associated protein of synapse-110, Chapsyn-110
Postsynaptic density protein PSD-93
Gene name: Dlg2, Dlgh2
As low as
€598.00
In stock
Ref
00096590
Chapsyn-110 is a member of the membrane-associated putative guanylate kinase (MAGUK) family. It binds directly to the NMDA receptor and Shaker K+ channel subunits and is 70-80% identical to PSD-95/SAP90 and SAP97. It mediates clustering of both NMDA receptors and K+ channels in heterologous cells. The encoded protein forms a heterodimer with PSD-95 that may interact at postsynaptic sites to form a multlimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins.
| ID Covalab | mab60077 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | S18-30 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Fusion protein corresponding to aa 1-852 of rat Chapsyn-110 (accession no. Q63622). This sequence is 94% homologous with human and 99% homologous with mouse Chapsyn-110. |
| Activity cross reaction | Reacts with mouse, rat and human (weak) Chapsyn-110. It does not react with PSD-95, SAP97, or SAP102. |
| Species | Ms, Rat |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | NaN3 0.09% |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Chapsyn-110 |
| Uniprot ID | Q63622 |
| Gene ID | 64053 |
| Applications | ICC, IF, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB 1 - 10 µg/ml ICC/IF 0.1 - 10 µg/ml IHC-P 0.1 - 1 µg/ml |
| Positive control | Rat brain lysate. |
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