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DNA/RNA Oxidative Damage Markers (15A3) antibody
8-hydroxy-2’-deoxyguanosine, oh8dG
8-hydroxyguanine, oh8G
8-hydroxyguanosine, oh8G
8-hydroxyguanine, oh8G
8-hydroxyguanosine, oh8G
As low as
€523.00
In stock
Ref
00096627
8-hydroxy-2’-deoxyguanosine (oh8dG), 8-hydroxyguanine (oh8G), and 8-hydroxyguanosine (oh8G) are markers of oxidative damage to DNA and RNA.
| ID Covalab | mab60114 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 15A3 |
| Isotype | IgG2b |
| Raised in | Mouse |
| Immunogen | 8-hydroxyguanosine (oh8G)-BSA and –casein conjugates. |
| Activity cross reaction | Reacts with 8-hydroxy-2’-deoxyguanosine (oh8dG), 8-hydroxyguanine (oh8G), and 8-hydroxyguanosine (oh8G). |
| Species | Euk |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | 0,1% NaN3 |
| Storage instructions | This antibody is stable for at least one year at 4°C. Avoid repeated freeze-thaw cycles. Do not freeze as this might result in precipitation of the antibody. |
| Target | DNA/RNA Oxidative Damage |
| Applications | ELISA, IHC, IP |
| Working dilutions | Optimal dilution should be determined by the end user. |
| Publication | Tanaka M, et la. Oxidized messenger RNA induces translation errors. Proc Natl Acad Sci U S A. 2007 Jan 2,104(1):66-71. Salganik RI, et al. Dietary antioxidant depletion: enhancement of tumor apoptosis and inhibition of brain tumor growth in transgenic mice. Carcinogenesis. 2000 May,21(5):909-14. Cui J, et al. Oxidative damage to the c-fos gene and reduction of its transcription after focal cerebral ischemia. J Neurochem. 1999 Sep, 73(3):1164-74. Nunomura A, et al. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. J Neurosci. 1999 Mar 15,19(6):1959-64. Park EM, et al. Assay of excised oxidative DNA lesions: isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proc Natl Acad Sci U S A. 1992 Apr 15,89(8):3375-9. |
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