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GRP78 (6H4-2G7) antibody
78 kDa glucose-regulated protein, GRP-78
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein, BiP
Gene name: HSPA5, GRP78
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78
Heat shock 70 kDa protein 5
Immunoglobulin heavy chain-binding protein, BiP
Gene name: HSPA5, GRP78
As low as
€489.00
In stock
Ref
00096716
Categorized as stress response proteins, BiPs play an important role in folding and assembly of nascent proteins and in scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5- nontranslated region of BiP mRNA. BiP IRES activity increases when cells are heat-stressed. GRP78 is also important in maintenance of cell homeostasis and the prevention of apoptosis. Levels of GRP78 protein are reduced in brains of Alzheimer’s disease patients.
| ID Covalab | mab60203 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 6H4-2G7 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | His-tagged human GRP78 (accession no. NP_001156906.1) |
| Activity cross reaction | Reacts with human GRP78. Cross-reacts with mouse, rat, bovine, hamster, rabbit, monkey, xenopus and fungi (Cryphonectria parasitica) protein. |
| Species | Fg, Hu, Ma, Ms, Rat, Xe |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | NaN3 0.09% |
| Storage instructions | For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt. |
| Target | GRP78 |
| Uniprot ID | P11021 |
| Gene ID | 3309 |
| Applications | ELISA, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : WB (0.5 - 1.0 µg/ml) |
| Positive control | HeLa cell |
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