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DcR1 (Extracellular Domain) antibody
Tumor necrosis factor receptor superfamily member 10C
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1, DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen: CD263
Gene name: TNFRSF10C, DCR1, LIT, TRAILR3, TRID
Antagonist decoy receptor for TRAIL/Apo-2L
Decoy TRAIL receptor without death domain
Decoy receptor 1, DcR1
Lymphocyte inhibitor of TRAIL
TNF-related apoptosis-inducing ligand receptor 3, TRAIL receptor 3, TRAIL-R3
TRAIL receptor without an intracellular domain
CD_antigen: CD263
Gene name: TNFRSF10C, DCR1, LIT, TRAILR3, TRID
As low as
€662.20
In stock
Ref
00097811
TRAIL/Apo2L is a member of the TNF family that induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has an extracellular TRAIL-binding domain but lacks an intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 does not induce apoptosis but attenuates TRAIL-induced apoptosis.
| ID Covalab | pab60105 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Peptide corresponding to aa 149-167 at the extracellular domain (ED) of human DcR1 precursor (accession no. AF012536). |
| Activity cross reaction | Reacts with the extracellular domain of human, mouse and rat DcR1. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | DcR1 |
| Uniprot ID | O14798 |
| Applications | ICC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: ICC (10 µg/ml) WB (1 µg/ml) |
| Positive control | HeLa cells |
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