Phospholipid transfer protein (PLTP) antibody

PLTP (phospholipid transfer protein) belongs to lipid transfer/lipopolysaccharide-binding proteins (BPI/LBP) family and it is a monomeric sectered protein expressed ubiquitously with highest expression in liver, one of the major sites of lipoprotein production and degradation. PLTP converts HDL into larger and smaller particles, and play a key role in extracellular phospholipid transport as well as modulation of HDL particles. Plasma PLTP is also considered a nonspecific lipid transfer protein because, along with phospholipids, it can also transfer alpha-tocopherol, diacylglycerol, cerebroside, and lipopolysaccharides. PLTP deficient mice depicts lowered susceptibility for atherosclerosis, whereas, PLTP transgenic mice have more atherosclerosis. In humans, an increased PLTP activity been linked to several conditions including type I/II diabetes mellitus, metabolic syndrome, obesitas, increased risk of coronary artery disease and cardiovascular disease.