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MAP1S pS812 antibody
Microtubule-associated protein 1S (MAP-1S)
BPY2-interacting protein 1
Microtubule-associated protein 8
Variable charge Y chromosome 2-interacting protein 1 (VCY2-interacting protein 1, VCY2IP-1)
Gene name: MAP1S, BPY2IP1, C19orf5, MAP8, VCY2IP1
BPY2-interacting protein 1
Microtubule-associated protein 8
Variable charge Y chromosome 2-interacting protein 1 (VCY2-interacting protein 1, VCY2IP-1)
Gene name: MAP1S, BPY2IP1, C19orf5, MAP8, VCY2IP1
As low as
€465.00
In stock
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00118044
MAP1S (Microtubule Associated Protein 1 S) is the shorter member of the MAP1 family of microtubule binding proteins. MAP1S gets cleaved post-translationally into heavy and light chains can regulate microtubule stability and dynamics. CDKL5 phosphorylates MAP1S at two residues on its light chain’s microtubule binding domain: S786 and S8122. MAP1S pSer812 antibody recognizes this phosphorylation specifically as MAP1S Ser812A phosphomutant is not recognized by pSer812 antibody. This phosphorylation site is conserved in human MAP1S S900.
| ID Covalab | pab01033-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic phospho-peptide surrounding Serine 812 from mouse MAP1S |
| Activity cross reaction | Predicted to cross react with proteins from human MAP1S phospho Serine 812 |
| Species | Ms, Rat |
| Labelling | None |
| Form | Purified (Antigen affinity purified) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | MAP1S pS812 |
| Uniprot ID | Q66K74 |
| Gene ID | 55201 |
| Applications | WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : WB (1:1000) |
| Publication | * Baltussen LL, et al. Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics. The EMBO journal, (2018) Dec 14;37(24) * Orban-Nemeth Z, et al. Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family. The Journal of biological chemistry 280, 2257-2265 (2005) |
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