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Granzyme A antibody (CB9)
Granzyme A
CTL tryptase
Cytotoxic T-lymphocyte proteinase 1
Fragmentin-1
Granzyme-1
Hanukkah factor (H factor, HF)
Gene name: GZMA, CTLA3, HFSP
CTL tryptase
Cytotoxic T-lymphocyte proteinase 1
Fragmentin-1
Granzyme-1
Hanukkah factor (H factor, HF)
Gene name: GZMA, CTLA3, HFSP
As low as
€407.80
In stock
Ref
00119462
Granzyme A is a serine protease expressed in the cytoplasmic granules of T cells and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Similarly to granzyme B, granzyme A acts to destroy the target cells by proteolysis of their particular components. In case of granzyme A the targets are e.g. APEX1 (it destroys its oxidative repair activity), and nucleosome assembly protein SET (it disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA).
| ID Covalab | mab21328 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | CB9 |
| Isotype | IgG1 kappa |
| Raised in | Mouse |
| Immunogen | The mouse monoclonal CB9 recognizes granzyme A, a 28 kDa serine protease expressed intracellularly in activated Tc cells and NK cells. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 15 mM |
| Storage instructions | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label. |
| Target | Granzyme A |
| Uniprot ID | P12544 |
| Gene ID | 3001 |
| Applications | FC, ICC, IP |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : FC (5-10 µg/ml) |
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