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ALIX antibody (8E8)
Programmed cell death 6-interacting protein
PDCD6-interacting protein
ALG-2-interacting protein 1
ALG-2 interacting Protein-X
Hp95
Gene name: PDCD6IP, AIP1, ALIX, KIAA1375
PDCD6-interacting protein
ALG-2-interacting protein 1
ALG-2 interacting Protein-X
Hp95
Gene name: PDCD6IP, AIP1, ALIX, KIAA1375
As low as
$306.10
In stock
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00012915
Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
| ID Covalab | mab0083-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 8E8 |
| Isotype | IgG1 / Kappa |
| Raised in | Mouse |
| Immunogen | Purified recombinant human ALIX protein |
| Activity cross reaction | Reacts with human ALIX protein. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | ALIX |
| Uniprot ID | Q8WUM4 |
| Gene ID | 10015 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: WB (1:200 - 1:1000) IHC (1:100 - 1:500) |
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