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CRMP-1 antibody
Dihydropyrimidinase-related protein 1
(DRP-1)
Unc-33-like phosphoprotein 3 (ULIP-3)
Gene name: CRMP1, DPYSL1, ULIP3
(DRP-1)
Unc-33-like phosphoprotein 3 (ULIP-3)
Gene name: CRMP1, DPYSL1, ULIP3
As low as
$306.10
In stock
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00013400
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.
| ID Covalab | pab0114 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | A 15 residue synthetic peptide derived from C-terminal domain of human collapsing-response mediator |
| Activity cross reaction | Reacts with 65 kDa CRMP-1 from human, rat and mouse. Do not cross react with CRMP-2, CRMP-3, CRMP-4 or CRMP-5. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Collapsing-response mediator protein 1 (CRMP-1) |
| Uniprot ID | Q14194 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : -IHC : 1/500 - WB :1/2 000 |
| Publication | - Cheillan D. et al. Abnormal expression of truncated CRMP-1 protein in the brain cortex of MPSIIIB mice. Mol Genet Metab. 2008 May;94(1):135-8. Epub 2008 Mar 5. - Veyrac A. et al. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci. 2005;21:2635-48. - Bertin S. et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17. -Quach T. et al. Involvement of collapsin response mediator proteins in the neurite extension induced by neurotrophins in dorsal root ganglion neurons. Mol Cell Neurosci. 2004;25:433-43. - Charrier E. et al. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol Neurobiol. 2003;28:51-64. Review. - Ricard D et al. Isolation and expression pattern of human Unc-33-like phosphoprotein 6/collapsin response mediator protein 5 (Ulip6/CRMP5): coexistence with Ulip2/CRMP2 in Sema3a- sensitive oligodendrocytes. J Neurosci. 2001 ; 21:7203-14. - Honnorat J. et al. Ulip/CRMP proteins are recognized by autoantibodies in paraneoplastic neurological syndromes. Eur J Neurosci. 1999;11:4226-32. |
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