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Securin antibody
Esp1-associated protein
Pituitary tumor-transforming gene 1 protein (Tumor-transforming protein 1) (hPTTG)
Gene Name : PTTG1, EAP1, PTTG, TUTR1
Pituitary tumor-transforming gene 1 protein (Tumor-transforming protein 1) (hPTTG)
Gene Name : PTTG1, EAP1, PTTG, TUTR1
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$323.40
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00013751
Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
| ID Covalab | pab0756-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide derived from internal domain of the human Securin |
| Activity cross reaction | Reacts with human 22 kDa securin. May cross react with mouse and other species due to sequence homology. |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Securin |
| Uniprot ID | O95997 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: - WB : 1/200 to 1/1000 - IHC: 1/50 to 1/200 |
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