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Nucleolin antibody
Protein C23
Gene name : NCL
Gene name : NCL
As low as
$323.40
In stock
Ref
00106860
ucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.
| ID Covalab | pab0971-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide of human Nucleolin |
| Activity cross reaction | Reacts with Nucleolin from human, mouse and chicken. Reacts with all the modified and unmodified forms of nucleolin |
| Species | Chick, Hu, Ms |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Nucleolin |
| Uniprot ID | P19338 |
| Gene ID | 4691 |
| Applications | IF, IP, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: - WB : 1/500 to 1/2000 - IF: 1/200 to 1/1000 |
| Publication | * I Ugrinova et al. Nucleolin Interacts and Co-Localizes with Components of Pre-Catalytic Spliceosome Complexes. Sci, 2019 * Cong R et al. Interaction of nucleolin with ribosomal RNA genes and its role in RNA polymerase I transcription. Nucleic Acids Res. 2012 Oct:40(19):9441-54. |
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