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MyD88 antibody
Myeloid differentiation primary response protein MyD88
Gene name : MYD88
Gene name : MYD88
As low as
$323.40
In stock
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00106872
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
| ID Covalab | pab0972-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide of derived from internal part of human Myd88 |
| Activity cross reaction | Reacts with Myd88 from human, mouse, rat, monkeys and other species (due to 100% sequence homology) |
| Species | Hu, Mk, Ms, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | MyD88 |
| Uniprot ID | Q99836 |
| Gene ID | 4615 |
| Applications | ELISA, ICC, IF, WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: - WB : 1/500 to 1/2000 - ICC, IF: 1/200 to 1/1000 |
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