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EGLN3 antibody
Egl nine homolog 3
HPH-1
Hypoxia-inducible factor prolyl hydroxylase 3, HIF-prolyl hydroxylase 3, HPH-3
Prolyl hydroxylase domain-containing protein 3, PHD3
Gene name: EGLN3
HPH-1
Hypoxia-inducible factor prolyl hydroxylase 3, HIF-prolyl hydroxylase 3, HPH-3
Prolyl hydroxylase domain-containing protein 3, PHD3
Gene name: EGLN3
As low as
$323.40
In stock
Ref
00106949
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site.
| ID Covalab | pab0984-P |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide of derived from internal part of human EGLN3. |
| Activity cross reaction | Reacts with EGLN3 from human, mouse and rat. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | None |
| Storage instructions | Lyophilized powder stable for a minimum of 2 years at -20°C. Store reconstituted antibodies at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | EGLN3 |
| Uniprot ID | Q9H6Z9 |
| Gene ID | 112399 |
| Applications | ELISA, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: IHC 1:100 - 1:1000 WB 1:200 - 1:2000 |
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