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PUMA antibody
Bcl-2-binding component 3
JFY-1
p53 up-regulated modulator of apoptosis
Gene name: BBC3, PUMA
JFY-1
p53 up-regulated modulator of apoptosis
Gene name: BBC3, PUMA
As low as
$528.40
In stock
Ref
00101407
PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53.Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway.
| ID Covalab | pab52058 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | 17 residue sequence [EQHLESPVPSAPGALAG] from exon-3-encoded region of human PUMA-alpha and PUMA-beta forms of the protein. <br/>88% sequence identity with rat and mouse proteins. |
| Activity cross reaction | Reacts with human PUMA protein. Recognizes both forms of the protein. |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | PUMA |
| Uniprot ID | Q9BXH1 |
| Applications | WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB (1:250 - 1:1000) |
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