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CD230 antibody (EM-21)
Major prion protein (PrP, ASCR, PrP27-30, PrP33-35C, CD230)
Gene name: PRNP, ALTPRP, PRIP, PRP
Gene name: PRNP, ALTPRP, PRIP, PRP
As low as
$698.80
In stock
Ref
00118526
CD230 / Human prion protein (PrP), also known as PRNP, is a ubiquitously expressed GPI-anchored cell surface glycoprotein associating with lipid raft components and functioning as a signaling molecule. CD230 / PrP plays a role in apoptosis in a cell context-dependent manner, is involved in proliferation of epithelial cells and in distribution of junction-associated proteins in human enterocytes. Conversion of this normal cellular prion protein (PrPc) into an abnormal conformer (PrPSc) is the crucial step associated with triggering the pathogenesis of the prion neurodegenerative disorders, such as the Creutzfeld-Jakob disease (CJD). Whereas PrPc is rich in alpha-helices, the PrPSc form has higher content of beta-sheets and is resistant to proteinase K.
| ID Covalab | mab21292 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | EM-21 |
| Isotype | IgG2a |
| Raised in | Mouse |
| Immunogen | The mouse monoclonal antibody EM-21 recognizes human prion protein (PrP). Diglycosylated form of PrP has ~ 40 kDa, monoglycosylated form ~ 30 kDa, and nonglycosylated form ~ 19-21 kDa. |
| Activity cross reaction | Recombinant human prion protein |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 15 mM |
| Storage instructions | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label. |
| Target | PRNP |
| Uniprot ID | P04156 |
| Gene ID | 5621 |
| Applications | WB |
| Working dilutions | Optimal dilution should be determined by the end user. |
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