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CD2 antibody (RM2-5)
T-cell surface antigen CD2 (LFA-2, CD2)
LFA-3 receptor
Lymphocyte antigen 37 (Ly-37)
Gene name: Cd2, Ly-37
LFA-3 receptor
Lymphocyte antigen 37 (Ly-37)
Gene name: Cd2, Ly-37
As low as
$399.30
In stock
Ref
00118528
CD2 belongs to T lymphocyte glycoproteins of immunoglobulin superfamily. Its interaction with CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection.
| ID Covalab | mab21293 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | RM2-5 |
| Isotype | IgG2b lambda |
| Raised in | Rat |
| Immunogen | The rat monoclonal antibody RM2-5 recognizes an extracellular epitope of CD2, a 50 kDa glycoprotein present on the human peripheral blood T lymphocytes and NK cells; also expressed by all thymocytes. |
| Activity cross reaction | Mouse thymocytes |
| Species | Ms |
| Labelling | None |
| Form | Purified (protein A) |
| Preservative | NaN3 15 mM |
| Storage instructions | Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label. |
| Target | CD2 |
| Uniprot ID | P08920 |
| Gene ID | 12481 |
| Applications | FC, IP |
| Working dilutions | Optimal dilution should be determined by the end user. |
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