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CD340 antibody (24D2) [FITC]
Receptor tyrosine-protein kinase erbB-2
Metastatic lymph node gene 19 protein (MLN 19)
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
CD340
Gene name: ERBB2, HER2, MLN19, NEU, NGL
Metastatic lymph node gene 19 protein (MLN 19)
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
CD340
Gene name: ERBB2, HER2, MLN19, NEU, NGL
As low as
$549.70
In stock
Ref
00118534
The oncoprotein ErbB2/HER2 (human epidermal growth factor receptor 2), also known as Neu or CD340, is a 185 kDa transmembrane tyrosine kinase of cell surface growth factor receptor family. It is present in a wide variety cell types of normal human fetal and adult tissues and is frequently overexpressed in human carcinomas (e.g. in 20-30% cases of breast cancer cells). Activation of ErbB2 triggers intracellular signalling events, which are essential for cell growth and differentiation. In the last 20 years ErbB2 antigen has become very important marker and therapy target in patient care.
| ID Covalab | mab21296 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 24D2 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | The mouse monoclonal antibody 24D2 recognizes an extracellular epitope of human CD340 (HER-2), a type I transmembrane protein expressed by mesenchymal stem cells, B-lymphoblastic leukemia cells, subsets of C-ALL blasts, and and various types of carcinomas. |
| Activity cross reaction | NIH-3T3/huCD340 cells |
| Species | Hu |
| Labelling | FITC |
| Form | Purified (liquid chromatography) |
| Preservative | NaN3 15 mM |
| Storage instructions | Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label. |
| Target | CD340 |
| Uniprot ID | P04626 |
| Gene ID | 2064 |
| Applications | FC |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: - FC: 4 μl for 100 μl of whole blood or 10^6 cells in a suspension. |
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