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ADAM17 (aa807-823) antibody
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17)
Snake venom-like protease
TNF-alpha convertase
TNF-alpha-converting enzyme
CD156b
ADAM18, MGC71942, Tumor necrosis factor alpha converting enzyme
Gene name : ADAM17, CSVP, TACE
Snake venom-like protease
TNF-alpha convertase
TNF-alpha-converting enzyme
CD156b
ADAM18, MGC71942, Tumor necrosis factor alpha converting enzyme
Gene name : ADAM17, CSVP, TACE
Out of stock
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00015637
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway
| ID Covalab | pab70244 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from human ADAM17. |
| Activity cross reaction | Reacts with human TACE. Cross reacts with mouse and rat protein. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.02% |
| Storage instructions | +4°C or -20°C, Avoid repeated freezing and thawing. |
| Target | ADAM17 |
| Accession Number | P78536 |
| Applications | IHC - P, WB |
| Working dilutions | IHC - P (20 µg/ml), WB |
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