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ATG5 antibody
ATG5
Autophagy protein 5, APG5-like,
Apoptosis-specific protein
Gene name: ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5
Autophagy protein 5, APG5-like,
Apoptosis-specific protein
Gene name: ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5
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00019503
Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity.
| ID Covalab | pab72230 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide from human ATG5 (amino acid 1-50). |
| Activity cross reaction | Reacts with APG5L from human, bovine, mouse, pufferfish, porcine, rat and zebrafish |
| Species | Hu, Ma, Ms, Pfi, Rat, Zfi |
| Labelling | None |
| Form | Antigen affinity purified |
| Preservative | NaN3 0.05% |
| Storage instructions | Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. |
| Target | ATG5 |
| Uniprot ID | Q9H1Y0 |
| Gene ID | 9474 |
| Applications | IF, IHC - P |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IHC-P (5 µg/ml), |
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