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APE-1 antibody (13B8E5C2)
DNA-(apurinic or apyrimidinic site) lyase, APE-1
APEX nuclease, APEN
Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1
REF-1
Redox factor-1
Gene name: APEX1, APE, APE1, APEX, APX, HAP1, REF1
APEX nuclease, APEN
Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1
REF-1
Redox factor-1
Gene name: APEX1, APE, APE1, APEX, APX, HAP1, REF1
As low as
$528.40
In stock
Ref
00024787
Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents.
| ID Covalab | mab50001 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | 13B8E5C2 |
| Isotype | IgG2b |
| Raised in | Mouse |
| Immunogen | Purified human APE1 (the epitope is within amino acids 80-100.) |
| Activity cross reaction | Reacts with APE-1 from human, mouse, primate, rat |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | NaN3 0.05% |
| Storage instructions | Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles. |
| Target | DNA-(apurinic or apyrimidinic site) lyase |
| Uniprot ID | P27695 |
| Gene ID | 328 |
| Applications | ChIP, GS, ICC, IF, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : ChIP (1:10-1:500) ICC/IF (1:50-1:200) IHC (1:100) IHC-F (1:10-1:2000) IHC-P (1:100) IP (1:10-1:500) WB (1:100-1:2000) |
| Publication | * Thomson B et al. Histology-specific expression of a DNA repair protein in pediatric rhabdomyosarcomas. J Pediatr Hematol Oncol. 2001 May:23(4):234-9. (IHC, Human) * Park SY et al. X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. Cancer Res. 2002 Jan15:62(2):459-65. (ICC/IF, WB, Human) |
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