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Rad17 antibody
Gene name: RAD17
As low as
$528.40
In stock
Ref
00029082
Signals originating from damaged DNA activate checkpoint pathways and target the mitotic apparatus via a number a distinct mechanisms.These checkpoints link damage to DNA with the components of the cell cycle through signal transduction systems.
In mammals, five genes have been identified as components of DNA damage-induced checkpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma.When overexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulation of G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpoint pathway.
In mammals, five genes have been identified as components of DNA damage-induced checkpoint pathways: ATM, p53, p21/WAF1/CIP1, hCHK1, and 14-3-3sigma.When overexpressed in mammalian cells, hRAD17 activates p53 and causes an accumulation of G1 phase cells, suggesting an involvement of the hRAD17 gene in this checkpoint pathway.
| ID Covalab | pab50509 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide made to a N-terminal region of human RAD17. |
| Activity cross reaction | Reacts with human Rad17 |
| Species | Hu |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.01% |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt. |
| Target | Rad17 |
| Applications | FC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: - WB : 1/500 to 1/1 000 |
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