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DUX4 (P2B1) antibody
Double homeobox protein 4
Double homeobox protein 10, DUX10
Gene name : DUX4
Double homeobox protein 10, DUX10
Gene name : DUX4
As low as
$586.30
In stock
Ref
00096632
Facioscapulohumeral muscular dystrophy (FSHD) is caused by the deletion of a subset of D4Z4 macro-satellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues, and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues.
| ID Covalab | mab60119 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | P2B1 |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag. |
| Activity cross reaction | Reacts with human DUX4. It does not cross-react with DUX4c. |
| Species | Hu |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | None |
| Storage instructions | This antibody is stable for at least one year at -20°C. |
| Target | DUX4 |
| Uniprot ID | Q9UBX2 |
| Gene ID | 100288687 |
| Applications | IF, IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : IF (1:10 - 1:500) IHC (1:10 - 1:500) WB (1:1000) |
| Publication | Snider L, et al. Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene. PLoS Genet. 2010 Oct 28,6(10):e1001181. |
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