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FKBP52 (Hi52C) antibody
Peptidyl-prolyl cis-trans isomerase FKBP4, PPIase FKBP4
51 kDa FK506-binding protein, FKBP51
52 kDa FK506-binding protein, FKBP-52
59 kDa immunophilin, p59
FK506-binding protein 4, FKBP-4
FKBP59
HSP-binding immunophilin, HBI
Immunophilin FKBP52
Rotamase
Gene name : FKBP4
51 kDa FK506-binding protein, FKBP51
52 kDa FK506-binding protein, FKBP-52
59 kDa immunophilin, p59
FK506-binding protein 4, FKBP-4
FKBP59
HSP-binding immunophilin, HBI
Immunophilin FKBP52
Rotamase
Gene name : FKBP4
As low as
$685.30
In stock
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00096695
FK506-binding proteins, FKBP51 and FKBP52, are high molecular weight immunophilins that are part of the mature glucocorticoid receptor heterocomplex. The N-terminal domains of these proteins bind FK506 and have peptidyl-prolyl isomerase activity that converts prolyl peptide bonds within target proteins from cis- to transproline. The C-terminal domains contain the tetratricopeptide repeats that are involved in protein-protein interactions with Hsp90. Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptors differently and have different Hsp90-binding characteristics. In addition, FKBP51 is linked to the progesterone receptor while FKBP52 is linked to progesterone, androgen, and glucocorticoid receptors.
| ID Covalab | mab60182 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Monoclonal antibody |
| Clone | Hi52C |
| Isotype | IgG1 |
| Raised in | Mouse |
| Immunogen | Recombinant full-length FKBP52 with an N-terminal polyhistidine tag. |
| Activity cross reaction | Reacts with human FKBP52. Cross-reacts with mouse, rat, canine and hamster protein. |
| Species | Ca, Ham, Hu, Ms, Rat |
| Labelling | None |
| Form | Purified (protein G) |
| Preservative | 0.09% NaN3 |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | FKBP52 |
| Uniprot ID | Q02790 |
| Gene ID | 2288 |
| Applications | FC, ICC, IHC, IP, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : FC (1-2 µg for 10.6 cells) IHC (4 - 5 µg/ml) WB (0.5 - 1 µg/ml) |
| Positive control | HeLa cell lysate, rat kidney and rat/mouse testes tissue. |
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