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APP (C-Terminus) antibody
Amyloid beta A4 protein
BPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Gene name: APP, A4, AD1
BPP
APPI, APP
Alzheimer disease amyloid protein
Cerebral vascular amyloid peptide, CVAP
PreA4
Protease nexin-II, PN-II
Gene name: APP, A4, AD1
As low as
$738.10
In stock
Ref
00097728
Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The β-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ-secretase to generate the 4 kD amyloid-β peptide which is deposited in the brain.
| ID Covalab | pab60022 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Peptide corresponding to aa 737-751 of human amyloid protein precursor (APP) or aa 85-99 of the C99 fragment generated by β- secretase cleavage. The sequences are identical to those of monkey, mouse, rat, chicken, and a variety of other species |
| Activity cross reaction | Reacts with the human, mouse, and rat APP and the C99 fragment. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | APP |
| Uniprot ID | P05067 |
| Applications | WB |
| Working dilutions | Optimal dilutions should be determined by the end user. The following are guidelines only: WB 1:500-1:1,000 |
| Positive control | Mouse brain |
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