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DR4 (C-Terminus) antibody
Tumor necrosis factor receptor superfamily member 10A
Death receptor 4
TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1
CD_antigen: CD261
Gene name: TNFRSF10A, APO2, DR4, TRAILR1
Death receptor 4
TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1
CD_antigen: CD261
Gene name: TNFRSF10A, APO2, DR4, TRAILR1
As low as
$645.70
In stock
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00097826
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. Another cell death receptor was recently identified and designated DR4. The ligand for DR4 has been designated TRAIL and is a new member of the TNF family. Therefore, DR4 is also called TRAIL receptor-1. DR4 is expressed in most human tissues including spleen, peripheral blood, small intestine, and thymus. Like TNFR1, Fas and DR3, DR4 mediates TRAIL-induced apoptosis and NF-kB activation in many tissues and cells.
| ID Covalab | pab60120 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Peptide corresponding to aa 427-445 at the C-terminus of human DR4 (accession no. ACC51226) |
| Activity cross reaction | Reacts with the C-terminus part of human DR4. |
| Species | Hu |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | DR4 |
| Uniprot ID | O00220 |
| Applications | ICC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: ICC (10 µg/ml) WB (1 µg/ml) |
| Positive control | HeLa cells |
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