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ERK1 + ERK2 antibody
Mitogen-activated protein kinase 3 & Mitogen-activated protein kinase 1
Extracellular signal-regulated kinase 1 & Extracellular signal-regulated kinase 3
ERK-1 & ERK-2
Gene name: MAPK3, MAPK1
Extracellular signal-regulated kinase 1 & Extracellular signal-regulated kinase 3
ERK-1 & ERK-2
Gene name: MAPK3, MAPK1
As low as
$512.60
In stock
Ref
00097837
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors.
| ID Covalab | pab60131 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | 35 amino acid synthetic peptide corresponding to ERK1 conjugated to KLH. |
| Activity cross reaction | Reacts with human Erk1 and Erk2. Cross-reacts with mouse, rat, chicken, sheep, bovine, drosophila and xenopus protein. |
| Species | Chick, D. mel., Hu, Ma, Ms, Xe |
| Labelling | None |
| Form | Antiserum |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt. |
| Target | Erk1 + Erk2 |
| Uniprot ID | P27361, P28482 |
| Applications | WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : WB 1:5000 |
| Positive control | HeLa cell |
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