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PARK7 antibody
Protein DJ-1
Oncogene DJ1
Parkinson disease protein 7
Gene name: PARK7
Oncogene DJ1
Parkinson disease protein 7
Gene name: PARK7
As low as
$607.40
In stock
Ref
00097960
Park7/DJ-1 is one of several genes thought to cause autosomal-recessive early-onset parkinsonism. Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.
| ID Covalab | pab60254 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide corresponding to amino acids 167-189 (AIVEALNGKEVAAQVKAPLVLKD) of human PARK7 conjugated to KLH at the N-terminus. |
| Activity cross reaction | Reacts with human and mouse PARK7. Sequence homology to mouse and rat DJ-1 is 82%. |
| Species | Hu, Ms |
| Labelling | None |
| Form | Purified |
| Preservative | None |
| Storage instructions | Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt. |
| Target | Park7 |
| Uniprot ID | Q99497 |
| Gene ID | 11315 |
| Applications | WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only : WB 1:500 |
| Positive control | HEK293 cell lysate or mouse brain tissue lysate |
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