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Smac (C-Terminus) antibody
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$738.10
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00098007
Inhibitors of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases has been identified and designated Smac/DIABLO. Smac is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates the cytochrome c/Apaf-1/caspase-9 pathway. The N-terminal amino acids of Smac are required for binding to IAPs and for activation of caspases. Smac is expressed in a variety of human and mouse tissues.
| ID Covalab | pab60301 |
|---|---|
| Product type | Primary antibodies |
| Clonality | Polyclonal antibody |
| Raised in | Rabbit |
| Immunogen | Synthetic peptide corresponding to the C-terminus part of (aa 225-239) of human Smac (accession no. AAF87716) |
| Activity cross reaction | Reacts with human, mouse and rat Smac. |
| Species | Hu, Ms, Rat |
| Labelling | None |
| Form | Purified |
| Preservative | NaN3 0.02% |
| Storage instructions | Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles. |
| Target | Smac |
| Applications | IHC, WB |
| Working dilutions | Optimal dilution should be determined by the end user. The following are guidelines only: WB (1 µg/ml) IHC (5µg/ml) |
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