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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
BAFF (CD257) is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, but also by T cells, activated B cells, some malignant B cells and non-lymphoid cells. BAFF binds three distinct receptors: BAFF-R (CD268), TACI (CD267) and BCMA (CD269), expressed predominantly on B cells. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cells differentiation. BAFF also co-stimulates activated T cells. Elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases. BAFF has also increased levels in some lymphoid cancers.
APRIL (CD256) is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It also interacts with heparan sulfate proteoglycans that induce APRIL oligomerisation, which is a prerequisite for the triggering of its effects on BCMA or TACI. It is implicated in the regulation of tumor cell growth and is involved in monocyte/macrophage-mediated immunological processes. APRIL produced by neutrophils sustains local antibody production by creating plasma cell niches in mucosa-associated lymphoid tissue (MALT).