Tumor Necrosis Factors Superfamily

TNF-related products from Covalab

 

LIGANDS :

RECEPTORS :

CD27 plays a key role in several immunological pathways such as T-cell differentiation into effector cells, B cell activation and immunoglobulins synthesis. CD27-deficiency leads to poor immunity against Epstein-Barr virus and is occasionally fatal. CD27 ligand (CD70) is expressed by highly activated lymphocytes while not by normal lymphocytes, and could be a possible target for the treatment of hematopoietic tumors.