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Tumor Necrosis Factors Superfamily
TNF-related products from Covalab
LIGANDS :
RECEPTORS :
NGFR (CD271) is a 75 kDa low affinity receptor for the Nerve Growth Factor (NGF), the Brain-derived Neurotrophic Factor (BDNF), and other neurotrophins such as NT-3 and NT-4, and whose main role lies in neuron survival and differentiation. Its ligands also bind to high affinity NGF receptors such as TrkA, TrkB and TrkC, which then balance its actions in normal conditions.
Studies have recently shown that NGFR could be involved in the development of the eyes and sensory neurons, as well as in muscle and nerves repair. It has also been reported that NGFR is highly expressed in melanoma tumor stem cells, and therefore could be a marker of this type of cancer.